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Janne Kudsk Klitgaard on Muck Rack

Janne Kudsk Klitgaard

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Articles

Bacteria-host transcriptional response during endothelial invasion by Staphylococcus aureus

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By Christian Garde, Claes Søndergaard Wassmann, Rasmus Birkholm Grønnemose, Janne Kudsk Klitgaard
| Nature Verified
Abstract Staphylococcus aureus is the cause of serious vascular infections such as sepsis and endocarditis. These infections are notoriously difficult to treat, and it is believed that the ability of S. aureus to invade endothelial cells and persist intracellularly is a key mechanism for persistence despite ongoing antibiotic treatment. Here, we used dual RNA sequencing to study the simultaneous transcriptional response of S. aureus and human endothelial cells during in vitro infections.
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