Jannet Koelewijn on Muck Rack

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Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors.

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By Juliane Buhl, Stijn De Munter, Victoria Cruz, Jannet Koelewijn
| biorxiv.org
Abstract Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant rhabdoid tumor and patient-matched normal kidney organoids to identify potential CAR T cell targets.
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