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Janou A.Y. Roubroeks on Muck Rack

Janou A.Y. Roubroeks

As seen in: BioRxiv
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Articles

Epigenome-wide profiling in the dorsal raphe nucleus highlights cell-type-specific changes in TNXB in Alzheimer′s disease

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By Ehsan Pishva, Artemis Iatrou, Renzo J.M. Riemens, Janou A.Y. Roubroeks
| BioRxiv
Abstract Recent studies have demonstrated that the dorsal raphe nucleus (DRN) is among the first brain regions affected in Alzheimer′s disease. Hence, in this study we conducted the first comprehensive epigenetic analysis of the DRN in AD, targeting both bulk tissue and single isolated cells. The Illumina Infinium MethylationEPIC BeadChip array was used to analyze the bulk tissue, assessing differentially modified positions (DMoPs) and regions (DMoRs) associated with Braak stage.
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