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Editor’s summary Structured Abstract Abstract Long-term isolation and bottlenecks strongly structure genetic variation in Near Oceania Archaic hominin introgression in Near Oceania Natural selection and archaic introgression Functional characterization of archaic introgressed variants Acknowledgments Supplementary Materials References and Notes Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary Between 2 and 5% of modern Eurasian...
Keywords ribosome assembly quality control ubiquitin-proteasome system CRISPRi development ribosomopathy Introduction The eukaryotic ribosome is a complex molecular machine responsible for translating mRNA to protein.
Abstract Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that take part in numerous interdependent steps. This complexity creates a large genetic space in which pathogenic mutations can occur. Dead-end ribosome intermediates that result from biogenesis errors are rapidly degraded, affirming the existence of quality control pathway(s) that monitor ribosome assembly.
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