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Jared Edwards

As seen in: Nature, JAMA (The Journal of the American Medical Association), Hidden Wires
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Articles by Jared Edwards

A transferable gut microbiota–bile acid pathway programs nanomedicine pharmacokinetics and therapeutic response

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By Mengyu Chang, Yifan Wang Verified, JongHoon Ha, Zoey R. Neale, Nadim J. Ajami, Laurence P Diggs, Ansel P. Nalin, Yifan Ma, Shiyan Dong, Abderrahman Day, Seong Dong Jeong, Annette Wu, Benjamin R. Schrank, Jared Edwards, Tianyu Wang, Xiaotian Wang, Yen-Tzu Chang, Chaoyang Tang, Anthony Lim, Michelle Torres, Weiye Deng, Sangeeta Goswami, Dadi Jiang, Albert C. Koong, Padmanee Sharma, Jennifer Wargo, Wen Jiang, Betty Kim, Yasmine M. Hoballah, Timothy Peitsch, Maurice J. Dufilho IV
| Nature Verified
Abstract The clinical efficacy of nanomedicines is often limited by hepatic sequestration, yet the endogenous programs determining this clearance state remain incompletely understood. Here we identify the gut microbiota as a regulator of nanomedicine biodistribution through bile-acid-associated programming of Kupffer cell phagocytic state.
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Skeletal-muscle-targeted non-viral delivery of full-length DMD mRNA for Duchenne muscular dystrophy

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By Yu Tian, Yutong Liu, Yuhao Tong, Kristin Huntoon, Liqun Yang, Junfeng Shi, Yifan Ma, Shiyan Dong, Seong Dong Jeong, You Yi, Kwang Joo Kwak, Yifan Wang Verified, Annette Wu, Jared Edwards, Xiaotian Wang, Yen-Tzu Chang, Jianhong Cao, Huan Zhang, Man Sun, Adam Grippin, Zhaogang Yang, Wen-Jing Lu, LY Lee, Eman Bahrani, Hongjia Zhang, Long Bai, Patricia Nguyen, Wen Jiang, Feng Lan, Betty Kim, Andrew Lee Verified, Andreanne Poppy Estania
| Nature Verified
Abstract Duchenne muscular dystrophy (DMD) is a severe, progressive muscle-wasting disorder caused by mutations in the DMD gene, which encodes dystrophin. Although gene therapy using viral vectors has shown promise for the treatment of DMD, the clinical application of viral gene therapies is limited by vector toxicity, immunogenicity and the inability to package full-length dystrophin.
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Association of Sarcopenia With Oncologic Outcomes of Primary Surgery or Definitive Radiotherapy Among Patients With Localized Oropharyngeal Squamous Cell Carcinoma | Facial Plastic Surgery | JAMA Otolaryngology-Head & Neck Surgery | JAMA Network

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By Brennan Olson, Jared Edwards, Lucas Stone, Angie Jiang
| JAMA (The Journal of the American Medical Association) Verified
Original Investigation June 11, 2020 JAMA Otolaryngol Head Neck Surg. 2020;146(8):714-722. doi:10.1001/jamaoto.2020.1154 Key Points Question Is the selection of primary treatment modality associated with survival among patients with sarcopenia and localized oropharyngeal squamous cell carcinoma?
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Installers turn out for inaugural Invision

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By Charlotte Ashley, Jared Edwards
| Hidden Wires Verified
Jared Edwards, technical training manager at Luxul, speaking on the importance of networking in residential installations Installers and industry experts alike filled the conference space at Runnymede-on-Thames Hotel in Surrey for Invision’s Smart Home Innovation Conference 2018. The one-day event offered the opportunity for attendees to listen to manufacturers discuss key points of discussion in the current CI landscape, as well as see exclusive product previews and network with industry peers.
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