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Yifan Wang

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Articles

Programming fracture resistance in metamaterials via elastic instabilities

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By Yujia Wang, Yangchengyi Liu, Kunlin Wu, Xuan Zhang, Hanzheng Xing, Songyan Zhang, Changhong Linghu, Yifan Wang Verified, Xiaoyan Li, Huajian Gao
| Nature Verified
Abstract The design of fracture-resistant materials has long been hindered by the complexity of toughening mechanisms across multiple length scales1,2. Mechanical metamaterials offer a promising platform to address this challenge, yet existing research has largely focused on passively characterizing fracture in conventional lattice architectures3,4,5,6,7,8.
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Time-resolved proteolipidomics of the human aorta identifies stage-specific lipid-protein modules across development and aging

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By HAO CUI, Yiqi Zhao, Yuan Jay Chang, MengDa Xu, Ningning Zhang, Yifan Wang Verified, Dongxing Zhu, Xiumeng Hua, Xiao Chen, Qian Zhao, Han Mo, Guanghou Shui, Jiangping Song, Jingkang Cui
| Cell Reports Verified
We next investigated temporal dynamics of the aortic proteome and lipidome across the human lifespan using Mfuzz (Figure 3A).
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Bclaf1 drives heart failure by recruiting Srsf2 to enhance Hand2 pre-mRNA splicing and pathological hypertrophy

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By Yang Zhang, Haiyu Gao, Ying Lu, Yingzi Zhang, Xiaofang Zhang, Yinfeng Zhao, Liying Yu, Shuang Wang, Lexin Zhao, Guohui Yang, Jialiang Li, Jiaxin Yu, Chenhong Li, Changzhu Li, Yifan Wang Verified, Ying Yang, YUE LI, Luyang Yu, Deli Zhao, Lida Yang, Lei Jiao, Baofeng Yang, Yanjie Lu, Zhenwei Pan, Yinghe Zhai
| Nature Verified
Abstract Heart failure with reduced ejection fraction (HFrEF) remains a major therapeutic challenge. B-cell lymphoma 2-associated transcription factor 1 (Bclaf1) is implicated in RNA splicing and cardiac disease, but its role in HFrEF pathogenesis is unknown. Here, we demonstrate that Bclaf1 expression is elevated in human HFrEF myocardium and in male murine pressure-overload models.
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