Jared Rosenblum

Abstract The central nervous system is surrounded by three interconnected membranes referred to as the meninges, which host a diverse immune network1,2,3. Within the skull-interfacing dura mater are venous sinuses, large veins that are traditionally viewed as passive blood drains for the brain and skull4,5. However, these structures also constitute an important neuroimmune interface6,7,8.

Abstract Externe IDs PubMed 39426935

Abstract There is increasing interest in how immune cells in the meninges—the membranes that surround the brain and spinal cord—contribute to homeostasis and disease in the central nervous system1,2. The outer layer of the meninges, the dura mater, has recently been described to contain both innate and adaptive immune cells, and functions as a site for B cell development3,4,5,6. Here we identify organized lymphoid structures that protect fenestrated vasculature in the dura mater.