Jaslovleen Kaur

Section 1 A 70-year-old Chinese woman developed slowed movements and difficulty walking over 6 years, with progressively worsening mobility. Her posture had become noticeably stooped in the past year and she had had tremors in both hands for at least a decade. Her family reported cognitive decline over 6 years, which was gradual and non-fluctuating, with problems in episodic memory, planning and multitasking.

http://orcid.org/0000-0002-3362-2717Shermyn Neo1, Jaslovleen Kaur2, Adeline SL Ng1, Tchoyoson CC Lim3 1Department of Neurology, National Neuroscience Institute, Singapore 2Neuro Clinics, Mohali, Punjab, India 3Department of Neuroradiology, National Neuroscience Institute, Singapore Correspondence to Dr Shermyn Neo, Neurology, National Neuroscience Institute, Singapore, Singapore; shermyn_neo{at}hotmail.com Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of...

Acute lymphoblastic leukaemia (ALL) is one of the most common malignancies of childhood. ALL is treated with high doses of methotrexate (MTX) to prevent central nervous system (CNS) and haematological relapses. MTX is administered intravenously and via intrathecal route.1 MTX can cause neurotoxicity by disrupting CNS folate homeostasis or by direct neuronal damage.