Jasminder Chana on Muck Rack

Jasminder Chana

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Ion-Pairing with Spermine Targets Theophylline To the Lungs via the Polyamine Transport System

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By Stuart Jones, David Barlow, Faiza Benaouda, Jasminder Chana
| American Chemical Society
Certain xenobiotics, such as paraquat, are sequestered into the lungs from the systemic circulation by the polyamine transporter system (PTS). The aim of this study was to investigate whether ion-pairing a drug (theophylline) with a PTS substrate (spermine) provides a means of using this active transport mechanism to target drug delivery to the lungs.
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