Jason Daniel Buenrostro on Muck Rack

Jason Daniel Buenrostro

As seen in: Cell Reports Medicine
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Articles

Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay

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By Tristan Tay, Gayathri Bommakanti, Elizabeth S. Jaensch, Aparna Gorthi, Yan Hu, Ruochi Zhang, Verena Brucklacher-Waldert, Laura B Prickett, Michael Overstreet, Steven W. Criscione, Iswarya Karapa Reddy, Aatman S. Doshi, James Kurasawa, Jason Daniel Buenrostro, Deanna A. Mele
| Cell Reports Medicine Verified
Introduction In patients with cancer, tumor-specific T cells are driven to exhaustion in the tumor microenvironment and become non-functional. Immune checkpoint therapies directed at blocking inhibitory receptors have shown great promise across several tumor types, albeit effective only in some patients.
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