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Articles

Shared genetic basis for migraine and ischemic stroke

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By Pankaj Sharma, Boukje de Vries, Tobias Kurth, Sudha Seshadri, George Smith, Dale R Nyholt, Verneri Anttila, Bendik S Winsvold, Peter M. Rothwell, Jonathan Rosand, Rainer Malik, Tobias Freilinger, Jason Vander Heiden, Matthew Traylor, Elizabeth G. Holliday, Gisela M. Terwindt, Jonathan Sturm, Joshua C. Bis, Jemma C. Hopewell, Michel D. Ferrari, Kristiina Rannikmae, Maija Wessman, Mikko Kallela, Christian Kubisch, Myriam Fornage, James F. Meschia, Terho Lehtimäki, Cathie Sudlow, Robert Clarke, Daniel I. Chasman, Braxton D. Mitchell, Jane Maguire, Jaakko Kaprio, Martin Farrall, Olli T. Raitakari, M. Arfan Ikram, Alex P. Reiner, W. T. Longstreth Jr., David P. Strachan, Lydia Quaye, Lynn Cherkas, Markus Schürks, Lannie Ligthart, Giorgio B. Boncoraglio, Kari Stefansson, Bradford B. Worrall, Hugh S. Markus, Chris Cotsapas, John A. Zwart, Aarno Palotie, Martin Dichgans
| Neurology Verified
Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci for both disorders, looking for potential overlap of signals.
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