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Jassim DiPalermo

As seen in: The BMJ
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Articles

High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties

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By Shruti Desai, Joanna Gibson, Janie Yue Zhang, Jassim DiPalermo
| The BMJ Verified
Results Treatment-naïve CRCs display cancer cell MGMT protein upregulation To study the localized expression of MGMT protein in CRC and its association with DDR and local adaptive antitumor responses, we established a multiplexed QIF panel to simultaneously map the markers DAPI for all nucleated cells, MGMT protein, γH2AX, CD8 for effector T cells and pan-CK for epithelial and malignant cells.
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