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Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening

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By Andy Ryan, Stuart Campbell, Elizabeth Benjamin, Susan Davies, Jatinderpal Kalsi, Aleksandra Gentry-Maharaj, Anne Dawnay, Mariam Habib, Sophia Apostolidou, Naveena Singh, Matthew Burnell, Aarti Sharma, Richard Gunu, Keith Godfrey, Alberto Lopes, David Oram, Jonathan Herod, Karin Williamson, Mourad W. Seif, Howard Jenkins, Tim Mould, Robert Woolas, John B. Murdoch, Stephen Dobbs, Nazar N. Amso, Simon Leeson, Derek Cruickshank, Lesley Fallowfield, Martin Widschwendter, Karina Reynolds, Alistair McGuire, Mahesh Parmar, Steven J. Skates, Ian Scott
| Journal of Clinical Oncology Verified
Patients and Methods In the United Kingdom Collaborative Trial of Ovarian Cancer Screening, 46,237 women, age 50 years or older underwent incidence screening by using the multimodal strategy (MMS) in which annual serum cancer antigen 125 (CA-125) was interpreted with the risk of ovarian cancer algorithm (ROCA). Women were triaged by the ROCA: normal risk, returned to annual screening; intermediate risk, repeat CA-125; and elevated risk, repeat CA-125 and transvaginal ultrasound.
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