Javed H. Tunio

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1. Introduction Cancer cells arise from normal cells with uncontrollable growth and unregulated cell cycles. Since these cells are of the same lineage as normal cells, the immune system is unable to recognize the malignancy. The tumor cells produce new proteins, mutate, and evade the immune defense mechanisms, leading to “immunoediting”. Immunoediting refers to the cancerous cells’ ability to selectively produce tumor molecules that will be undetected by the immune response.