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Jawahar Kopparam on Muck Rack

Jawahar Kopparam

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Articles

PRC2 loss impairs small cell lung cancer tumorigenesis and enhances sensitivity to G9a/GLP inhibition - Communications Biology

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By Jawahar Kopparam, Gayathri Chandrasekaran, Danielle Hulsman, Liesa-Marie Pilger, Karen Stevers, Ji-Ying Song, Miguel Hernández-Quiles, Jelmer Dijkstra, Jitendra Badhai, Nick Landman, Michiel Vermeulen, Maarten van Lohuizen
| Nature Verified
Abstract Effective targeted therapies for small cell lung cancer (SCLC) remain a significant challenge. Targeting the epigenome to overcome immune evasion and chemoresistance represents a promising strategy to improve treatment outcomes. In this study, we explored the role of Polycomb repressive complex 2 (PRC2), a key transcriptional repressor, by dissecting its structural and enzymatic functions.
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