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Articles by Jay Loeffler
Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities
1. Young HH On the presence of nerves in tumours and of other structures in them as revealed by a modification of Ehrlich's method of “ vital staining “ with methylene blue. J Exp Med. 1897; 2: 1-12 2. Scherer HJ Structural development in gliomas. Am J Cancer. 1938; 34: 333-351 3. Batsakis JG Nerves and neurotropic carcinomas. Ann Otol Rhinol Laryngol. 1985; 94: 426-427 4. Liebig C Ayala G Wilks JA Berger DH Albo D Perineural invasion in cancer: a review of the literature. Cancer. 2009; 115: 3379-3391 5.
Charged-particle therapy in cancer: clinical uses and future perspectives
Key Points Owing to their physical properties, the therapeutic use of charged particles in radiotherapy is advantageous over photon-based radiotherapy The delivery of charged particles is more costly than that of X-rays, with no level 1 evidence currently indicating clinical superiority of either approach Randomized trials are essential to establish the clinical benefit derived from charged-particle therapy; several studies are currently ongoing worldwide The design of clinical trials for the...
Safety of combining radiotherapy with immune-checkpoint inhibition
The excitement surrounding the potential synergy between radiotherapy and ICI might prove to be a double-edged sword. In both patients and mouse models, radiotherapy has been shown to diversify the TCR repertoire, leading to the priming and activation of naive T cells that recognize TAAs7,40.
Three ways to make proton therapy affordable
If cost was not an issue, proton therapy would be the treatment of choice for most patients with localized tumours. Protons can be targeted more precisely than X-rays1, so the tissues around the tumour receive two to three times less radiation. This lowers the chance of causing secondary tumours2 or impairing white blood cells and the immune system3. High doses of protons can be delivered safely to hard-to-treat tumours: for instance, those at the base of the skull or in the liver.
Help emergency services find you
As of the first part of May 2016, there was an exchange between the Wisconsin Department of Transportation and La Crosse County where a portion of Hwy. 108 was swapped for a portion of (La Crosse) County Hwy. C. The highways are approximately 10-mile stretches of road between the towns of Farmington and Hamilton.
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