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William L Hwang on Muck Rack

William L Hwang

As seen in: LinkedIn, Nature, Wiley Online Library, Gut Journal, MDPI, Genome Biology, JAMA Oncology, Cell Press, Texas Medical Center, Future Medicine and
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Articles

Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo

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By Muhammad Khan, Jinhee Chang, Amol C Shetty, Triet M. Nguyen, Aaron Chan, Priyanshi Patel, Jiayu Chen, Jarey Wang, Matthew Ballew, Francesca Carrieri, Reem Malek, Hailun Wang, Noelle Thielman, Keyu Li, Ryan Park, William L Hwang, Lei Zheng, Kathleen L Gabrielson, Phuoc T. Tran, Audrey Lafargue, Danielle N. Waters, Dipanwita Dutta Chowdhury, Elan Simms, Hwai Wei Tseng, Lucas T. Tran, Katriana Nugent, Ghali Lemtiri-Chlieh
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with poor survival outcomes. Genomic analyses have identified distinct molecular subtypes in human PDAC with the quasimesenchymal/squamous/basal-like (QSB) subtype having the worst prognosis. However, no in vivo models exist for QSB subtypes. The epithelial–mesenchymal transition (EMT) transcription factor TWIST1 is upregulated in QSB PDAC.
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Upfront memory T cell add-back with haploidentical TCRαβ-depleted graft in adults with haematological malignancies: a nationwide, multicentre, single-arm, prospective study | Bone Marrow Transplantation

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By Aloysius Ho, William L Hwang, Liang-Piu Koh
| Nature Verified
Abstract In haploidentical hematopoietic cell transplantation (Haplo-HCT), in vivo or ex vivo T-cell depletion (TCD) can prevent graft-versus-host disease (GVHD) but increase risk of infection and relapse. We hypothesized that TCRαβ-depleted allograft together with upfront infusion with CD45RA-depleted memory T cells (αβTCD + TMDLI) may result in favourable GVHD-free and relapse-free survival (GRFS).
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Integrating Priorities at the Intersection of Cancer and Neuroscience

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By William L Hwang
| Texas Medical Center
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