Jay Michael Yarbro on Muck Rack

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Articles

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

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By Masihuz Zaman, Shu Yang, Ya Huang, Jay Michael Yarbro
| biorxiv.org
Abstract Proteomic profiling of Alzheimer's disease (AD) brains has identified numerous understudied 34 proteins, including midkine (MDK), that are highly upregulated and correlated with Aβ since the 35 early disease stage, but their roles in disease progression are not fully understood. Here we 36 present that MDK attenuates Aβ assembly and influences amyloid formation in the 5xFAD 37 amyloidosis mouse model.
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Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

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By Xian Han, Abhijit Dasgupta, Danting Liu, Jay Michael Yarbro
| biorxiv.org
Abstract Murine models of Alzheimer's disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. We comprehensively profiled age-dependent brain proteome and phosphoproteome (n > 10,000 for both) across multiple mouse models of amyloidosis. We identified shared pathways by integrating with human metadata, and prioritized novel components by multi-omics analysis.
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