Nuclear factor kappa light chain enhancer of activated B cells (NFkB) is a ubiquitous transcription factor with varied roles within the mammalian cell. While best known for its regulation of inflammation and innate immunity, NFkB has a wide range of gene targets and can influence complex behaviors such as learning and memory, addiction and depression. This review will highlight these diverse functions, and draw links between specific gene targets and the development of addictive-like behaviors.
