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Jayasankar M. Kaimal on Muck Rack

Jayasankar M. Kaimal

As seen in: Nature
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Articles

Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70

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By Roman Kityk, Chammiran Daniel, Jayasankar M. Kaimal, Jobst Liebau
| Nature Verified
Protein quality control depends on the tight regulation of interactions between molecular chaperones and polypeptide substrates. Substrate release from the chaperone Hsp70 is triggered by nucleotide-exchange factors (NEFs) that control folding and degradation fates via poorly understood mechanisms.
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