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AbOmpA induces host cell death through both early-onset apoptosis and delayed-onset necrosis [105]. When epithelial cells are exposed to rAbOmpA, both the full-length and subfragments of rAbOmpA are detected in the cytoplasm within 4–8 h, after which subfragments of rAbOmpA move to the nuclei [133]. The cytoplasmic rAbOmpA binds to the voltage-dependent anion channel (VDAC) in the outer membrane of mitochondria (unpublished data).
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