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Jea Kwon on Muck Rack

Jea Kwon

As seen in: Nature, BioRxiv, Cell Metabolism
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Articles

Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination - Experimental & Molecular Medicine

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By Jea Kwon, Sunpil Kim, Junsung Woo, Keiko Tanaka-Yamamoto, Oliver James, Erik De Schutter, Sungho Hong, C. Justin Lee
| Nature Verified
Abstract Tonic inhibition in cerebellar granule cells is crucial for maintaining information coding fidelity during motor coordination. It arises through both activity-dependent and activity-independent mechanisms, and the interplay between these mechanisms changes with age. However, specific molecular and cellular mechanisms and how their change affects network-level computation and motor behavior remain unclear.
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Integrating artificial intelligence and optogenetics for Parkinson’s disease diagnosis and therapeutics in male mice - Nature Communications

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By Bobae Hyeon, Jaehyun Shin, Jae-Hun Lee, Jea Kwon, Choong Yeon Kim, Sian Choi, Jae-Woong Jeong, Kwang-Soo Kim, C. Justin Lee, Daesoo Kim
| Nature Verified
Abstract Parkinson’s disease (PD), a progressive neurodegenerative disorder, presents complex motor symptoms and lacks effective disease-modifying treatments. Here we show that integrating artificial intelligence (AI) with optogenetic intervention, termed optoRET, modulating c-RET (REarranged during Transfection) signalling, enables task-independent behavioural assessments and therapeutic benefits in freely moving male AAV-hA53T mice.
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Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination

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By Jea Kwon, Sunpil Kim, Junsung Woo, Erik De Schutter
| BioRxiv
Abstract Tonic inhibition in cerebellar granule cells (GC) is crucial in information coding fidelity for motor coordination. It emerges in activity-dependent and -independent manners, and their interplay evolves with age. However, specific molecular and cellular mechanisms and how their change affects network-level computation and motor behavior remain unclear.
Open in Who Shared Issue with article?
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