Jea Park on Muck Rack

Jea Park

As seen in: Nature
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Articles

Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome - Nature Communications

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By Christine Wu, Kristine A Tsantilas, Jea Park, Deanna Plubell, Gennifer E. Merrihew, Michael Riffle, Andrew N Hoofnagle, William Noble, Kathleen L. Poston, Thomas J. Montine
| Nature Verified
Abstract Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detection of proteins that are beyond the dynamic range of liquid chromatography-mass spectrometry of unfractionated plasma. Mag-Net is robust, reproducible, inexpensive, and requires <100 μL plasma input.
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Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome

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By Christine Wu, Jea Park, Deanna Plubell, Kristine J. Tsantilas
| biorxiv.org
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Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease - Nature Communications

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By Gennifer E. Merrihew, Jea Park, Deanna Plubell, C. Dirk Keene, James Zou, Michael J MacCoss
| Nature Verified
Abstract Resilience to Alzheimer’s disease is an uncommon combination of high disease burden without dementia that offers valuable insights into limiting clinical impact. Here we assessed 43 research participants meeting stringent criteria, 11 healthy controls, 12 resilience to Alzheimer’s disease and 20 Alzheimer’s disease with dementia and analyzed matched isocortical regions, hippocampus, and caudate nucleus by mass spectrometry-based proteomics.
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