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Deficiency of N-linked glycosylation impairs immune function of B7-H6
1 Introduction Natural Killer (NK) cells are the most abundant subset of innate lymphoid cells (ILCs) in peripheral blood, and serve as one of the most important immune surveillance defense lines against virus or other intracellular pathogens-infected cells, senescent cells and tumor cells (1, 2).
Therapeutic strategies targeting folate receptor α for ovarian cancer
1 Introduction Epithelial ovarian cancer (EOC) accounts for approximately 95% of ovarian cancer incidence, and is a leading cause of gynecologic cancer mortality worldwide (1, 2). Current standard-of-care treatment for newly diagnosed patients is cytoreductive debulking surgery plus neoadjuvant or post-operative platinum-based chemotherapy. Most patients initially respond to chemotherapy, but unfortunately up to 80% will eventually relapse leading to patient demise (3).
Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases
1Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway 2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Introduction: Inhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair.
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