Jean-Noel Lemercier on Muck Rack

Jean-Noel Lemercier

As seen in: Nature
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Mechanistic basis for improved activity of Engineered AsCas12a

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By Bryant Chica, André White, Steven Wolk, Linnea Jansson-Fritzberg, Chrysa Latrick, Andrea Olland, Alexey Dementiev, Steffen Kutter, Jean-Noel Lemercier
| Nature
Abstract CRISPR-associated proteins (Cas) are central to gene editing, forming nuclease complexes with guide RNA to enable precise genome modification. Among numerous Cas variants, Cas9 and Cas12a are the most extensively studied. While much is known about the genomic substrates for these enzymes, less is known about the determinants of the DNA cleavage activity. Wild-type Cas12a exhibits higher intrinsic specificity than Cas9, minimizing off-target activity, but lower overall potency.
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