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Introduction Germline mutations in breast cancer susceptibility genes gBRCA1 and gBRCA2 are estimated to occur in approximately 1–5% of all breast cancers.1 The BRCA1 and BRCA2 proteins function in the repair of double-stranded DNA breaks through homologous recombination.2 Therapeutic agents that inhibit DNA synthesis or repair mechanisms, including platinum-containing compounds and poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPis), have shown efficacy for treating gBRCA1/2...
To the Editor Preliminary reports have pointed out to an increased risk of thrombotic events in patients diagnosed with coronavirus disease 2019 (Covid-19)( 1 Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, et al. Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. 2020:e38.: https://www.nejm.org/doi/full/10.1056/NEJMc2007575 https://doi.org/10.1056/NEJMc2007575 , 2 Bangalore S, Sharma A, Slotwiner A, Yatskar L, Harari R, Shah B, et al.
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