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Articles by Jean Wright
Impact of Tamoxifen Only after Lumpectomy for “Good Risk” Duct Carcinoma in Situ: Combined Analysis of the NRG Oncology/RTOG 9804 and ECOG-ACRIN E5194 Trials
Get full text access Log in, subscribe or purchase for full access. REFERENCES 1. McCormick, B. ∙ Winter, K.A. ∙ Woodward, W. ... Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma Situ: Long-Term Report From NRG Oncology/RTOG 9804. JCO. 2021; 39:3574-3582 2. Wright, J.L. ∙ Gray, R. ∙ Rahbar, H. Lumpectomy without radiation for ductal carcinoma in situ of the breast: 20-year results from the ECOG-ACRIN E5194 study NPJ Breast Cancer. 2024; 10 3.
Frontline Multiple Myeloma Therapy: Kicking the Can Further Down the Road? | CancerNetwork
In January 2026, the FDA approved subcutaneous daratumumab and hyaluronidase-fihj (Darzalex Faspro) in combination with bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone (VRd) among adults with newly diagnosed multiple myeloma (NDMM) who are ineligible for autologous stem cell transplant. In a conversation with CancerNetwork®, Saad Z. Usmani, MD, MBA, FACP, FASCO, detailed the clinical implications of this regulatory decision.
RB-1355 Is Safe and Well-Tolerated in B- and T-Cell Lymphomas
RB-1355 monotherapy or in combination with radiotherapy demonstrated safety, tolerability, and preliminary efficacy among patients with B- and T-cell lymphomas, according to an oral presentation of the phase 1 FIH trial given at the 2026 Tandem Meetings.1 Specifically, among 13 patients treated with RB-1355, only 3 treatment-related adverse effects (TRAEs) were observed in 2 patients, none of which were grade 3 or higher.
FDA Grants Orphan Drug Designation to Zenocutuzumab in Cholangiocarcinoma
Zenocutuzumab-zbco (Bizengri) has received orphan drug designation from the FDA for the treatment of adults with advanced unresectable or metastatic cholangiocarcinoma (CCA), according to a press release from the developer, Partner Therapeutics, Inc.1 The designation represents a regulatory milestone for the bispecific antibody, which is designed to block the HER2-HER3 receptor axis driven by these rare oncogenic alterations.
Exploring the Bone Marrow Microenvironment’s Influence on NDMM Trajectory
In a conversation with CancerNetwork®, Manoj Bhasin, PhD, MS, spoke about findings from a study in which he and colleagues developed a single-cell atlas characterizing the dysregulation of the bone marrow immune microenvironment in newly diagnosed multiple myeloma. Findings published in Nature Cancer showed that the immune system has a broad, treatment-independent influence on outcomes in newly diagnosed multiple myeloma.
What to Consider After Diagnosing a Patient With Ductal Carcinoma In Situ
Although ductal carcinoma in situ (DCIS) is a precancer diagnosis, it remains a hot topic of discussion among radiation oncologists. At the 2026 American College of Radiation Oncologists Summit, Jean L. Wright, MD, FASTRO, delivered a presentation titled “Updates and Best Practices for DCIS,” which highlighted new research in DCIS.
Building Trust and Removing Barriers in Clinical Trial Diversity
Despite clinical trials being the engine of oncologic progress, representation remains a significant hurdle in achieving equitable outcomes. For Kathie-Ann Joseph, MD, MPH, FACS, bridging this gap requires more than just opening new study sites; it demands a fundamental shift in how the oncology community approaches patient trust and trial logistics.
Advancing Precision and Access in Breast Radiation Oncology
In a discussion at the 2026 American College of Radiation Oncology (ACRO) Summit, Parul Barry, MD, a radiation oncologist at University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center and Magee-Womens Hospital, highlighted the evolving landscape of breast cancer treatment.
ASCO President Elect Talks Advancing Patient-Centered Care and Team-Based Innovation
Oncology has transitioned from a generalist field to one of immense sub-specialization, expanding to nearly 1000 different therapeutic options.
Jean L. Wright, MD, FASTRO
Jean L. Wright, MD, FASTRO Articles by Jean L. Wright, MD, FASTRO According to Jean L. Wright, MD, FASTRO, the flow of new information and research pertaining to ductal carcinoma in situ is constant.
Why Discuss Ductal Carcinoma In-Situ at a Major Oncology Conference?
Among the many hot topics discussed at the 2026 American College of Radiation Oncology (ACRO) Summit, radiation therapy for breast cancer was discussed frequently. Jean L. Wright, MD, FASTRO, delivered one such presentation on breast cancer titled “Updates and Best Practices for [ductal carcinoma in situ (DCIS)]”. As evidenced by the name, she detailed the current updates and best practices for treating patients who are diagnosed with DCIS.
In Reply to Kunkler et al
Get full text access Log in, subscribe or purchase for full access. References 1. Kunkler, I.H. ∙ Russell, N.S. ∙ Anderson, N. ... In regard to ASTRO Int J Radiat Oncol Biol Phys. 2026; 125:662-663 2. What the SUPREMO trial means for patients considering radiation therapy after mastectomy 3. Kunkler, I.H. ∙ Russell, N.S. ∙ Anderson, N. ... Ten-year survival after postmastectomy chest-wall irradiation in breast cancer N Engl J Med. 2025; 393:1771-1783 5.
Radiotherapy Deserts: Impact of Race, Poverty and the Rural-Urban Continuum on Density of Providers and Utilization of Radiotherapy in the United States
Abstract Purpose : Prior efforts to characterize disparities in radiotherapy access and receipt have not comprehensively investigated interplay between race, socioeconomic status, and geography relative to oncologic outcomes.
Inside art advisor Amanda Love's uniquely updated Victorian villa
Contemporary art advisor Amanda Love and her businessman husband Andrew have made art their life, and their Sydney home, breathtaking in its proportions, is an artwork in its own right. Distinctive, classic, all white – the freestanding late-Victorian villa with rear stables looks very different from the Tuscan-style terracotta facade it presented when the couple bought it 30 years ago.
Patient Safety Awareness Week for Radiation Oncology - ASTRO Blog- American Society for Radiation Oncology (ASTRO) - American Society for Radiation Oncology (ASTRO)
This article was originally published in the American Association for Physicists in Medicine (AAPM) March/April newsletter. By Eric Ford, PhD, FASTRO, Sue Evans, MD, MPH, and Jean Wright, MD Patient Safety Awareness Week (PSAW) began in 2002 as annual event intended to encourage a continued focus on health care safety. This year it is observed March 13-19 and serves as a national education campaign for promoting patient safety practices.
External Validation of the Bone Metastases Ensemble Trees for Survival (BMETS) Machine Learning Model to Predict Survival in Patients With Symptomatic Bone Metastases | JCO Clinical Cancer Informatics
PURPOSE The Bone Metastases Ensemble Trees for Survival (BMETS) model uses a machine learning algorithm to estimate survival time following consultation for palliative radiation therapy for symptomatic bone metastases (SBM). BMETS was developed at a tertiary-care, academic medical center, but its validity and stability when applied to external data sets are unknown.
Remembering our Lost Space Heroes – NASA KSC Day of Remembrance 2021: Photos - Space UpClose
Remembering our Lost Space Heroes – NASA KSC Day of Remembrance 2021: Photos Flowers honor the memory of NASA’s fallen astronaut heroes at Kennedy Space Center Visitor Complex in Florida annual ceremony held in front of the Space Mirror Memorial. Astronaut Memorial Foundation (AMF) on Jan. 28, 2021. Credit: Jean Wright/spaceupclose.com For SpaceUpClose.com KENNEDY SPACE CENTER VISITOR COMPLEX, FL – “Space is hard.” A commonly used expression often heard in our community.
New ‘Planet Play’ Immersive Kids Exhibit Grand Opening at Kennedy Space Center Visitor Complex: Photos
New ‘Planet Play’ Immersive Kids Exhibit Grand Opening at Kennedy Space Center Visitor Complex: Photos “Planet Play” is the newly opened interactive multi-story play and learning experience about space, astronomy and science for the new generation of space exploring kids at the Kennedy Space Center Visitor Complex in Florida! ‘Planet Play’ official Grand Opening Jan. 4, 2021.
A Spanish mission-style home filled with art
For gallerist and art adviser Sally Dan-Cuthbert collecting is a lifelong preoccupation. She grew up in a household that was always engaged in art and design. The ceiling of her childhood bedroom was papered with a Marion Hall Best design, while the first artwork her father bought her when she was a teenager (after seeing her emotional response to a woodblock print by Austrian expressionist Maximilian Kurzweil) now hangs in her dressing room. To buy from the heart was a lesson she learned early on.
An opulent family home
A Brutalist table and an art collection that covers the spectrum add surprise to these stylish interiors. Sep 11, 2020 5:59am For Christian Lyon, the starting point for any design project is to understand what energises a client and how they want to live. In the case of this home, the Perth-based interior designer had a head start.
Developing an Improved Statistical Approach for Survival Estimation in Bone Metastases Management: The Bone Metastases Ensemble Trees for Survival (BMETS) Model
ABSTRACT Background To determine if a machine learning approach optimizes survival estimation for patients with symptomatic bone metastases (SBM), we developed the Bone Metastases Ensemble Trees for Survival (BMETS) to predict survival using 27 prognostic covariates. To establish relative clinical utility, we compared BMETS to two simpler Cox regression models used in this setting.
Optimizing Radiotherapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists
Abstract Immunotherapy using immune checkpoint blockade has revolutionized the treatment of many types of cancer. Radiation therapy (RT)--particularly when delivered at high doses using newer techniques – may be capable of generating systemic anti-tumor effects when combined with immunotherapy in breast cancer. These systemic effects might be due to the local immune-priming effects of RT resulting in the expansion and circulation of effector immune cells to distant sites.
Crew Quarters - NASA Astronauts “Home Away from Home” Undergoes Modern Upgrades at Kennedy: Photos
Crew Quarters – NASA Astronauts “Home Away from Home” Undergoes Modern Upgrades at Kennedy: Photos Crew of STS-1 in Suit Preparation Room with tables for spacesuit hardware and medical monitoring gauges and panels with new recliner following refurbishment of the Neil Armstrong Operations and Checkout (O&C) Building at Kennedy Space Center.
Bringing the Taste of Home To Space - Baking 1st Cookies in Zero-G on ISS
Bringing the Taste of Home To Space – Baking 1st Cookies in Zero-G on ISS A front view of the Zero G Kitchen space oven launching to the International Space Station (ISS) on the Northrop Grumman Cygnus NG-12 cargo ship, showing where food samples are placed for cooking.
Standardizing Normal Tissue Contouring for Radiation Therapy Treatment Planning: Executive summary of an ASTRO Consensus Paper
Publication History Published online: December 18, 2018Accepted: December 8, 2018; Received in revised form: November 29, 2018; Received: September 4, 2018;
Jean Wright, July 9, 1932-Sept. 17, 2016 - Times-Citizen Communications: Obituaries
Jean Wright Posted: Wednesday, September 21, 2016 8:35 am | Updated: 8:36 am, Wed Sep 21, 2016. Jean Wright, July 9, 1932-Sept. 17, 2016 HUBBARD - Jean Wright, 84, of Hubbard, passed away Saturday, Sept. 17, 2016, at Hubbard Care Center. Funeral service was held Wednesday, Sept. 21, at the St. John's Evangelical Lutheran Church. Burial was in the Hubbard Cemetery. Memorial contributions may be directed to the Hubbard Care Center or Iowa River Hospice.
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