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Jeanette Baran‐Gale on Muck Rack

Jeanette Baran‐Gale

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Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

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By Stefano Maio, Lia Chappell, Fatima Dhalla, Jeanette Baran‐Gale
| embopress.org
Abstract To induce central T‐cell tolerance, medullary thymic epithelial cells (mTEC) collectively express most protein‐coding genes, thereby presenting an extensive library of tissue‐restricted antigens (TRAs). To resolve mTEC diversity and whether promiscuous gene expression (PGE) is stochastic or coordinated, we sequenced transcriptomes of 6,894 single mTEC, enriching for 1,795 rare cells expressing either of two TRAs, TSPAN8 or GP2.
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