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Jeanette Gowen Cook on Muck Rack

Jeanette Gowen Cook

As seen in: Nature, MDPI
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Articles

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination - Nature Communications

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By Derek L. Bolhuis, Dalia Fleifel, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas Brown
| Nature Verified
Abstract The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG unloading and replisome disassembly are poorly described. Since disassembly is catalyzed by ubiquitination, deubiquitinases (DUBs) represent attractive candidates for safeguarding against untimely and deleterious CMG unloading.
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G1 Dynamics at the Crossroads of Pluripotency and Cancer

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By Dalia Fleifel, Jeanette Gowen Cook, Jeanette Gowen, J. Gowen
| MDPI
1. Introduction In the complex world of cellular processes, two seemingly distinct entities—stem cells and cancer cells—converge at a surprising crossroad: their cell cycle dynamics. Stem cells during embryonic development are characterized by rapid proliferation which is reminiscent of the excessive and uncontrolled proliferation that is a hallmark of cancer [1,2].
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