Jeanette Hellgren Kotaleski

To characterize the learning rule, we started with a simple setup where three features, each illustrating either a color or a shape, were distributed onto two dendritic branches. The setup was such that one relevant and one irrelevant feature combination were represented in each dendrite and the relevant–irrelevant feature combination was unique to each dendrite (see illustration in Figure 3A).

Discussion Here, we developed a biochemically detailed model of GABABRs and their effects on neuronal excitability through their Giβγ-mediated interactions with GIRK channels and VGCCs. Our model has two important advances compared to existing models. Firstly, the model describes the GABABR and Giβγ activity in both pre- and postsynaptic terminals.

Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural diversity; type-specific connectivity; cortical microcircuit; across-trial variability; striatal microcircuit; correlation transfer; Parkinson s disease; spatial constraint; non-isotropic morphology; spatiotemporal sequences; neural mångfald; typ-specifik kopplingsmönster; kortikal mikrokrets; variabilitet mellan försök; striatal mikrokrets; korrelationsöverföring; Parkinsons sjukdom; rumsliga begränsningar;...