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Jeeval Mehta on Muck Rack

Jeeval Mehta

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Articles

Protective role of cGAS in NASH is related to the maintenance of intestinal homeostasis

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By Yeonhee Cho, Xiaojing Wang, Mrigya Babuta, Jeeval Mehta
| Wiley Online Library Verified
Abstract Background & Aims Various intracellular pathways regulate inflammation in NASH. Cyclic GMP-AMP synthase (cGAS) is a DNA sensor that activates STING and plays a role in inflammatory diseases. Here, we explored the role of cGAS in hepatic damage, steatosis, inflammation, and liver fibrosis in mouse models of NASH. Methods cGAS deficient (cGAS-KO) and STING deficient (STING-KO) mice received high fat-high cholesterol-high sugar diet (HF-HC-HSD) or relevant control diets.
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