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Jeff Danielson on Muck Rack

Jeff Danielson

Brainerd
As seen in: Nature, MDPI, BioRxiv, Des Moines Register, The Forum of Fargo-Moorhead, MinnPost, The Waterloo-Cedar Falls Courier, IP Watchdog, Journal of Physical Education, Recreation and Dance, Pontiac Daily Leader
VP Advocacy, Clean Grid Alliance. Navy Vet, Retired Firefighter & recovering State Senator. Policy Geek. Views my own. RT's≠Endorsement
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Articles

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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By Apoorva Uboveja, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan Cole, Richard Fang, Miho Naruse, Zhentai Huang, Emily Megill, Daniel S. Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M. Marcinkiewicz, Sarah Graff, Ellen De Pieri, Frank P. Vendetti, Jeff Danielson, Erika Dahl, Jennifer Pennise, Alison Jaccard, Kristine Cooper, Francesmary Modugno, Nadine Hempel, Wayne Stallaert, Christopher J. Bakkenist, Simone Sidoli, Kathryn Wellen, Benjamin G. Bitler, David Long, Nathaniel W Snyder, Katherine M. Aird, Baixue Yang, Julie A. Disharoon, Evan Levasseur, Andrea Andress Huacachino, Esther Elishaev, Lauren Borho
| Nature Verified
Abstract Homologous recombination (HR) deficiency increases sensitivity to DNA-damaging agents that are commonly used to treat cancer1. In HR-proficient cancers, the metabolic mechanisms that drive response or resistance to DNA-damaging agents remain unclear. Here we have identified that depletion of α-ketoglutarate (αKG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation.
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Wind energy projects provide local revenue | Opinion

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By Jeff Danielson
| Pontiac Daily Leader Verified
Illinois is a forward-thinking energy state. By being proactive and embracing cost-effective, sustainable energy sources, the state reaps substantial economic benefits and a reliable energy grid. Wind energy plays a significant role in realizing these benefits, contributing to the state’s goal of achieving clean energy sustainability.
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CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance

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By Raquel Buj, Aidan Cole, Jeff Danielson, Jimmy Xu
| BioRxiv
Abstract Approximately 50% of cancers exhibit decreased CDKN2A expression (CDKN2ALow), which is linked to immune checkpoint blockade (ICB) resistance. While CDKN2A is traditionally recognized as a tumor suppressor and cell cycle regulator, we have previously put forth a new paradigm demonstrating its role in intracellular metabolic reprogramming.
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