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To determine whether MN identity contributes to the specificity of connections within the ventral spinal cord, we examined the formation of sensory-motor reflex circuits under conditions where MN organization has been genetically altered. We first traced the central projections of sensory neuron (SN) afferents along the rostrocaudal axis in controls by injecting the lipophilic dye DiI into the dorsal root ganglia (DRGs) of postnatal day (P)0–P1 mice.
The accuracy of neural circuit assembly relies on the precise spatial and temporal control of synaptic specificity determinants during development. Hox transcription factors govern key aspects of motor neuron (MN) differentiation; however, the terminal effectors of their actions are largely unknown. We show that Hox/Hox cofactor interactions coordinate MN subtype diversification and connectivity through Ret/Gfrα receptor genes.
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