Jelien den Hollander on Muck Rack

Jelien den Hollander

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In Silico Assessment of Limited Blood Sampling Strategies for Individualised Pharmacokinetic‐guided Dosing of Efanesoctocog Alfa in Haemophilia A Patients

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By Marjon H. Cnossen, Jelien den Hollander
| Wiley Online Library Verified
1 Introduction Efanesoctocog alfa is a novel recombinant factor VIII (FVIII) concentrate approved for prophylactic, perioperative and on-demand treatment in patients with haemophilia A [1]. It features a unique molecular design that includes an Fc domain, two XTEN polypeptides and a Von Willebrand Factor (VWF) D'D3 FVIII binding domain, which prevents endogenous VWF from binding to the recombinant FVIII [2].
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