Jenna M. Bartley

Abstract Breast cancer is the second most common cancer globally, with most deaths caused by metastatic disease, often following long periods of clinical dormancy1. Understanding the mechanisms that disrupt the quiescence of dormant disseminated cancer cells (DCCs) is crucial for addressing metastatic progression. Infections caused by respiratory viruses such as influenza and SARS-CoV-2 trigger both local and systemic inflammation2,3.

Abstract Aging leads to dysfunction and decline in many tissues and body systems. Declines in physical function with age are mainly due to alterations in neurological, musculoskeletal, and cardiovascular functions. The hallmarks of aging denote the molecular and cellular processes that underlie aging physiology. Exercise can target multiple hallmarks of aging at a molecular and systems level, to prevent and in some cases reverse age-related declines.

Amor and colleagues previously developed chimeric antigen receptor (CAR) T cells that can target and eliminate senescent cells. The utility of these senolytic CAR T cells is now expanded to show that they can combat age-related metabolic dysfunction, and that they can be used prophylactically and have effects that persist for months, thus opening the door to the development of long-term senolytic approaches.