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Jennemiek van Arkel on Muck Rack

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Two opposing gene expression patterns within ATRX aberrant neuroblastoma

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By Linda Schild, Jennemiek van Arkel, Luuk A. Broeils, Bianca Koopmans
| paperity.org
PLOS ONE, Aug 2023 Neuroblastoma is the most common extracranial solid tumor in children. A subgroup of high-risk patients is characterized by aberrations in the chromatin remodeller ATRX that is encoded by 35 exons. In contrast to other pediatric cancer where ATRX point mutations are most frequent, multi-exon deletions (MEDs) are the most frequent type of ATRX aberrations in neuroblastoma.
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