Jennifer Huff

Integrating pharmacokinetic studies to guide the selection of doses in preclinical studies, thereby achieving target concentrations comparable to the human therapeutic range, is crucial for successfully translating animal drug development studies to clinical use. Stiripentol add-on to clobazam and valproic acid significantly reduced spontaneous seizure frequency in Scn1aA1783V/WT mice.

Abstract Background: Patients with drug-resistant epilepsy, including Dravet syndrome (DS), are frequently prescribed multiple antiseizure medications (ASMs). Nevertheless, people with DS often have inadequate seizure control, and there is an ongoing unmet clinical need to identify novel therapeutics.

The gathering came after more than 600 people were cited and released Wednesday in Minneapolis. ST PAUL, Minn. — A group of protest organizers gathered outside the Governor's Residence Thursday evening after more than 600 people were cited and released during a rally Wednesday night in Minneapolis. The citations came after people marched onto Interstate 94 between Highway 280 and Interstate 35W.