Jens Skorstengaard Andersen on Muck Rack

Jens Skorstengaard Andersen

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Articles

Molecular basis of polyadenylated RNA fate determination in the nucleus

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By Andrii Bugai, Ulrich Hohmann, Ana Lorenzo Verified, Max Graf, Laura Fin, Jérôme O. Rouvière, Laszlo Tirian, Yuhui Dou, Patrik Polak, Dennis Johnsen, Lis Jakobsen, Julius Brennecke, Clemens Plaschka, Torben Jensen, Marion Le Rest, Jens Skorstengaard Andersen
| Nature Verified
Abstract Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs1,2, which are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including protein-coding RNPs, are exported to the cytoplasm, whereas transcripts within non-functional pA+ RNPs are degraded in the nucleus1,2,3,4. How cells distinguish these opposing fates remains unknown.
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