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Jens Thiel

As seen in: Annals of the Rheumatic Diseases, Arthritis Research & Therapy

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Articles

Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis

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By Jens Thiel, Franziska Schmidt, Raquel Lorenzetti, Arianna Troilo
| Annals of the Rheumatic Diseases Verified
Materials and methods Patients included in this retrospective analysis were identified from the IR-Biobank and the FREEZE-biobank of the University Hospital Freiburg between 2012 and 2021. Clinical data were extracted from the database of the Department of Rheumatology and Clinical Immunology, University Hospital Freiburg.
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B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients | Arthritis Research & Therapy | Full Text

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By Jens Thiel, Marta Rizzi, Marie Engesser, Ann-Kathrin Dufner
| Arthritis Research & Therapy Verified
B cell depletion is effective in many autoimmune diseases. When B cell-targeted therapy is discontinued the effect wears off [13, 14] and therefore 6-monthly re-treatment schedules are common clinical practice. B cell repopulation kinetics are of crucial importance for the design of rituximab re-treatment schedules, but have to date not been systematically compared in different autoimmune diseases.
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