Jeong-Ok Lee

Dear Editor, Treatment strategies for newly diagnosed mantle cell lymphoma (MCL) vary substantially according to patient age, performance status, and comorbidities [1]. Intensive cytarabine-based regimens followed by upfront autologous stem cell transplantation (ASCT) has been preferred for younger or fit patients, while less intensive ones for older or frail patients. Rituximab maintenance therapy is recommended for both groups across major guidelines [2].

Clinical MedicineIn-Press PreviewHematologyOncology Open Access | 10.1172/jci.insight.164767 JCI Insight. https://doi.org/10.1172/jci.insight.164767. Copyright © 2022, Kim et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract BACKGROUND. Chronotherapy is a drug intervention at specific times of the day to optimize efficacy and minimize adverse effects.

The aim of the current study is to investigate the effects of spray dry powders of Curcuma longa containing 40% curcumin (CM-SD), as a new aqueous curcumin formula, on sarcopenia in chronic forced exercise executed 10 month old ICR mice. CM-SD (80 and 40 mg/kg) increased calf thicknesses and strengths, total body and calf protein amounts, and muscle weights in both gastrocnemius and soleus muscles.