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Jeremy Barbier

As seen in: PLOS, BioRxiv
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Articles

Decoding Nucleosome-Depleted Regions: Insights from Epigenetic Marks, Nucleosome Size, and Thermodynamic Modelling

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By Kevin Tartour, Jeremy Barbier, Kharerin Hungyo, Fabien Sassolas
| BioRxiv
Abstract Elucidating the global and local rules that govern genome-wide nucleosome organisation and chromatin architecture remains a critical challenge. Thermodynamic modelling based on DNA elastic properties predicts the presence of sequence-encoded nucleosome-inhibiting energy barriers (NIEBs) along vertebrate genomes. They delineate in vivo nucleosome-depleted regions (NDRs) flanked by 2-3 well positioned nucleosomes.
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Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

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By Jean-Michel Arbona, Laboratoire de Physique, Hadi Kabalane, Jeremy Barbier
| PLOS
Sensitivity of MRT and RFD with respect to model parameters. We performed simulations of whole genome replication to assess the sensitivity of MRT and RFD and S-phase duration to: (i) the density of firing factors ρF (number per Mb); (ii) the mean distance between potential origins dPO; (iii) the proportion of random initiation r; and (iv) fork speed v.
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