Jerena Manoharan

1 INTRODUCTION The autosomal dominant inherited disease multiple endocrine neoplasia type 1 (MEN1) is a rare disorder caused by germline MEN1 gene mutations on chromosome 11q13.1 However, recent research has not identified significant clinical, genotype–phenotype, or gender-associated differences in disease progression.2-5 Regular screening is recommended for MEN1 mutation carriers.6-9 Relying on more sensitive imaging modalities, current studies prove that non-functioning pancreatic...

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Abstract and Introduction Abstract Importance: Guidelines advocate subtotal parathyroidectomy (SPTX) or total parathyroidectomy with autotransplantation (TPTX) with bilateral cervical thymectomy for primary hyperparathyroidism (pHPT) associated with multiple endocrine neoplasia type 1 (MEN1). However, both procedures are associated with a significant risk of permanent hypoparathyroidism.