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Jesse Cheruiyot Rop on Muck Rack

Jesse Cheruiyot Rop

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Articles

Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases - Nature Communications

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By María Imaz, Alice Barnett, Carl A. Anderson, Jesse Cheruiyot Rop
| Nature Verified
Abstract Many disease-associated variants are thought to be regulatory but are not present in existing catalogues of expression quantitative trait loci (eQTL). We hypothesise that these variants may regulate expression in specific biological contexts, such as stimulated immune cells. Here, we used human iPSC-derived macrophages to map eQTLs across 24 cellular conditions. We found that 76% of eQTLs detected in at least one stimulated condition were also found in naive cells.
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