Jesse L. Bonin

Highlights • Sepsis drives emergency myelopoiesis and transient cytopenias • Persistent extramedullary myelopoiesis occurs in survivors of sepsis • Sepsis survivors are refractory to G-CSF-induced HSPC mobilization and granulopoiesis Summary Sepsis survivors exhibit immune dysfunction, hematological changes, and increased risk of infection. The long-term impacts of sepsis on hematopoiesis were analyzed using a surgical model of murine sepsis, resulting in 50% survival.

New Results doi: https://doi.org/10.1101/2022.10.03.510683 Abstract Opioids have long been used for clinical pain management, but also have addictive properties that have contributed to the ongoing opioid epidemic. While opioid activation of opioid receptors is well known to contribute to reward and reinforcement, data now also suggest that opioid activation of immune signaling via toll-like receptor 4 (TLR4) may also play a role in addiction-like processes.