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Articles by Jesse Mendoza
Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking
Highlights • D1 and D2 neuron activity in the NAc is elevated during behavioral suppression • Inhibition of D1 or D2 neurons in the NAc increases unproductive reward seeking • BLA and PVT axons innervate distinct NAc subregions, yet both inputs are reinforcing • Inhibition of BLA or PVT inputs to the NAc increases unproductive reward seeking Summary The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear.
Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value
Highlights • Operant choice behavior is driven by differences in expected value • Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value • Disrupting cue-evoked DA interferes with the maintenance of cue-value associations • Manipulations of cue-evoked DA signaling do not lead to under- or overexpectation Summary Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value, but its influence on reward assessment is unclear.
DJI Osmo Pocket Review: Say Goodbye To Shaky Running Videos
I’m not much of a video or photography expert, but I’d like to think I can tell a good photo or video when I see it. I like to take the time to shoot a decent photo for, say, my Instagram page, because I’d like to be able to enjoy it a few years from now. Lately, I’ve been on a quest to find the perfect hand-held stabilizer for my iPhone or GoPro for quite some time now. A stabilizer allows for shake-free video when you mount your iPhone or camera, such as a GoPro, to it.
App Review: Pocket - No Time To Read Now? Listen To It Later
I’ll take any news – political, local, world, tech, online blogs – anything that peaks my interest at the time. I enjoy reading about the things going on around me and always feel the need to know the latest and greatest the very minute it happens. I like to take in articles and news stories using my tablet, iPhone, and laptop since I’m using either one of those three at different times during my day.
Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption
Reward-seeking behavior is regulated by a diverse collection of inputs to the nucleus accumbens (NAc). The information encoded in each excitatory afferent to the NAc is unknown, in part because it is unclear when these pathways are active in relation to behavior. Here we compare the activity profiles of amygdala, hippocampal, and thalamic inputs to the NAc shell in mice performing a cued reward-seeking task using GCaMP-based fiber photometry.
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