Jesse Pereira

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description jbmb70029-sup-0001-FigureS1.pptxPowerPoint 2007 presentation , 11.8 MB Figure S1: Step-by-step protocol for root dentin assays and analysis by confocal microscopy. (A) Dentin block preparation and bacterial contamination.

Abstract Considering the presence of a complex biofilm and persistent inflammation in infected dental root canals, this study evaluated the cytotoxicity and inhibitory effect of phenolic acids on pro-inflammatory gene expression and multispecies biofilms for endodontic applications. First, cinnamic acid (CI) and caffeic acid (CA) were screened based on their inhibitory activity on oral bacteria and toxicity on fibroblasts and macrophages by colorimetric assays.

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jbma37895-sup-0001-Supinfo.docxWord 2007 document , 32.7 KB Figure S1. FTIR spectra of morin (M), morin-chitosan-poloxamer (MCP) and chitosan-poloxamer (CP) hydrogels.