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Jessica Barowski on Muck Rack

Jessica Barowski

As seen in: Nature
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Articles

An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration

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By Gilbert Gallardo, Jessica Barowski, John Ravits, Teepu Siddique
| Nature Verified
Abstract Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell–intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which causes familial amyotrophic lateral sclerosis (ALS).
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