CONFLICT OF INTEREST STATEMENT All authors are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ USA. REFERENCES 1, , . CHO cells in biotechnology for production of recombinant proteins: current state and further potential. Appl Microbiol Biotechnol. 2012; 93(3): 917-930. 2, . A review on the current methods of Chinese hamster ovary (CHO) cells cultivation for the production of therapeutic protein. Curr Drug Discov Technol. 2021; 18(3): 354-364. 3, .