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Jessica Quintin

As seen in: Color Research & Application, Nature
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Articles by Jessica Quintin

Bacterial toxin sensing induces transient inflammasome-dependent innate immune memory that improves survival during sepsis

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By Ludovic Batistic, Els Verhoeyen, Grégory Michel, Patrick Munro, Anne Doye, Alexandre Gallerand, Stoyan Ivanov, Dorota Czerucka, Orane Visvikis, Bénédicte F. Py, Jessica Quintin, Laurent Boyer, Cédric Torre, Valentine Marion, Zakaryia Caillot, Margot Saissi, Océane Dufies, Céline Loubatier, Paul Chaintreuil
| Nature Verified
Abstract Adaptive immune memory generated by bacterial toxin vaccination is well established, but whether bacterial toxins can also induce innate immune memory, or trained immunity (TI), remains unclear. Here, we show that bacterial toxins elicit TI through NLRP3 inflammasome activation both in vitro and in vivo in mice, and that this response is conserved in primary human macrophages.
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Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles

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By Elif Eren, David Williams, Giorgio Camilli, Vishukumar Aimanianda, Etienne Meunier, Jessica Quintin
| Color Research & Application Verified
Recognition of the fungal cell wall carbohydrate ?-glucan by the host receptor Dectin-1 elicits broad immunomodulatory responses, such as phagocytosis and activation of oxidative burst. These responses are essential for engulfing and killing fungal pathogens. Phagocytic monocytes are key mediators of these early host inflammatory responses to infection. Remarkably, whether phagocytosis of fungal ?-glucan leads to an inflammatory response in human monocytes remains to be established.
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