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Zakaryia Caillot on Muck Rack

Zakaryia Caillot

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Articles

Bacterial toxin sensing induces transient inflammasome-dependent innate immune memory that improves survival during sepsis

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By Ludovic Batistic, Els Verhoeyen, Grégory Michel, Patrick Munro, Anne Doye, Alexandre Gallerand, Stoyan Ivanov, Dorota Czerucka, Orane Visvikis, Bénédicte F. Py, Jessica Quintin, Laurent Boyer, Cédric Torre, Valentine Marion, Zakaryia Caillot, Margot Saissi, Océane Dufies, Céline Loubatier, Paul Chaintreuil
| Nature Verified
Abstract Adaptive immune memory generated by bacterial toxin vaccination is well established, but whether bacterial toxins can also induce innate immune memory, or trained immunity (TI), remains unclear. Here, we show that bacterial toxins elicit TI through NLRP3 inflammasome activation both in vitro and in vivo in mice, and that this response is conserved in primary human macrophages.
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